Boehringer Ingelheim Vetmedica GmbH

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Boehringer Ingelheim Animal Health Business Unit

Boehringer Ingelheim is the second largest animal health business in the world, with net sales of 4 billion euros in 2019 and presence in more than 150 markets.

As the lives of animals and humans are intertwined, across the globe, our 10,000 employees are dedicated to enhancing the well-being of both – through science and innovation, as well as with their commitment and passion.

Respect for animals, people and the environment is at the heart of what we do. We develop medicines, services and innovative digital technologies to protect animals from disease and pain. We support our customers in taking care of the health of their animals and protect our communities against life- and society- threatening diseases.

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微生物和病毒感染

22-11月-2017

本文对蓝耳病病毒(PRRS)和圆环病毒2型(PCV2)共同感染在临床症状,病变和病毒载量上的不同严重程度进行了研究。

Figure 2. Swollen eyes in an affected pig.

临床案例: 猪水肿

此案例概述了一商品猪场水肿病的爆发,且在不使用疫苗的情况下难以控制。自2014年起,欧洲水肿病爆发数量不断增加,但发病原因尚不清楚。

Three months pigs with PCV2-SD. Note the marked spine, indicative of growth retardation, and body pallor

猪圆环病毒2型的挑战:种间分类

猪圆环病毒2型(PCV2)已经成为对生猪生产破坏性最大的病毒,造成相当大的经济影响(直接损失和控制疾病的花费)。PCV2是断奶仔猪多系统衰竭综合征(PMWS)的病原体,目前被称为PCV2-系统性疾病(PCV2-SD, 图 1)。流行病学和和实验研究已证明基因多样性可能影响PVC2的毒力,表现为在全球范围内出现新的基因型以及重组株的流行。也许这正是为什么PCV2种间分类颇具争议的原因。2008年,欧盟猪圆环病毒病联盟提出了以成对基因序列比较为基础的PCV2基因型标准命名法(www.pcvd.eu)。通过分析PCV2完整和衣壳(ORF2)核苷酸序列确定了2个距离阈值,分别为0.020 和0.035。当2个序列之间的遗传距离大于这两个阈值时,认为这些毒株属于不同的基因型。分析发现了4种基因型,分别命名为PCV2a, PCV2b, PCV2c和 PCV2d(也被称为PCV2b突变型)。

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